Thursday, February 28, 2013

Having Problems coping - Talk About Marriage

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Hello all. I am new to this forum and am hoping I can get some advice on my issue that I am having. I have been married for less than a year and don't know what to do anymore. Let me start from the beginning:

I met my now husband back in 2009. Everything seemed great and things couldn't have been going better. The summer of 2010 I discovered that my husband had once taken anti depressants but was not doing so anymore. I didn't think much of it at that point. The only thing I knew my husband struggled with from the beginning was anxiety which he was taking a medicine for. Later on in the relationship I found out that his mom's side of the family had some more major mental health issues going on (ie BiPolar, Major depression, etc). My husband told me he never had the same feelings that they were experiencing and at that point I let it go because for one, it wasn't any of my business what types of issues his family was going through, and he seemed normal. Once we got married in 2012 things began to slowly change. He became more distant and snapped at me easier. He decided to go back to school and left a full time job for a part time job and always stated that he was "bored". I always showed concern asking if there was anything I could do to make it better or tired to get him to open up to why he felt the way he did with being bored and distant but I would always get shut out. He didn't care that it bothered me and he became very disrespectful to me with his language and telling me to "f off", etc. He also was drinking every night, sometimes almost a 12 pack a night which really upset me because i don't like to be around that. In October I basically told him that we needed to do something about how things were going and that we needed to go and talk to someone or he needed to as he was the one that was having the anger issues and not me. I even offered to go and talk to someone as well about how I should cope with this. He eventually told me he felt like he "had a problem" and needed to go back on anti depressants. I talked to him about it and suggested that he should have a doctor decide if he needed to go down that path. He then blamed his issues on his side of the family saying that he got his problems from there. I went to the doctors (psych) with him, where he basically just told the doctor that he needed to go back on anti depressants and told him how he was feeling. Doctor also told him maybe he needed to go on Abilify for light Bi-Polar but he had to promise he was going to stop the drinking. Well, that was almost 6 months ago and he still drinks and is now taking meds for anxiety, depression and bi-polar disorder and still acts the same as how he was before going in. I don't know what to do and I feel stuck. I don't want to give up on my marriage but I don't see how I am going to be happy with my life 5 years from now if nothing changes. How he acts and treats me makes him sexually unattractive which has now started arguments about not showing enough physical attention to one another. I am now questioning if I even want to have children anymore because I don't want my children to grow up around this and have some of the same mental issues as him (I have no mental history on my side of the family). I know this is bad to say because I don't know what goes through his head but I feel he uses some of the medicine as an excuse or an escape. For example, I had a low point last spring with a job and because I wasn't as happy as I usually was he told me I just needed to go on anti-depressants and that would make everything better.....which is not right. Everyone has not so great times in their lives but that doesn't automatically mean one has to go on drugs to supposedly make things better. I just need some advice. I don't know what to do anymore I would go and talk to someone about this but my new insurance will not cover it and I can't afford it. I appreciate you taking the time to read this.

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Source: http://talkaboutmarriage.com/anxiety-depression-relationships/68557-having-problems-coping-husband-anxiety-depression-bpd.html

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Q&A: Moving iTunes Libraries - NYTimes.com

Q.

How do I transfer my iTunes library from a desktop PC to a laptop, neither of which are Apple computers?

A.

All the items in your iTunes library, like music, TV shows and podcasts, are stored in folders on the computer. The iTunes software itself, which is basically a big database program crossed with a media player, displays the items in your library in lists and makes it relatively easy to manage your collection.

To move your library to a new computer, you just need to move your iTunes library folder from the old machine to the new one with a copy of the iTunes software installed. You can do this in several ways depending on how you use iTunes ? including transferring all the files over your network with the Home Sharing feature, copying your iTunes folder to an external hard drive or set of DVDs for transport between computers, or transferring content from the iTunes Store with an iPod, iPad or iPhone.

Apple has step-by-step, illustrated instructions for all these moving methods (and others) on its site. If you plan to get rid of the old computer, be sure to deauthorize it for use with your iTunes purchases, as explained here.

Source: http://gadgetwise.blogs.nytimes.com/2013/02/27/qa-moving-itunes-libraries/

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Monday, February 25, 2013

Huawei reveals 'fastest smartphone in the world'

This undated product image provided by Huawei, shows the Chinese company's new flagship model that it calls "the fastest smartphone in the world."The company said Sunday, Feb. 24, 2012, the device supports faster download speeds than other phones, but today's wireless networks aren't equipped to supply those speeds. (AP Photo/Huawei)

This undated product image provided by Huawei, shows the Chinese company's new flagship model that it calls "the fastest smartphone in the world."The company said Sunday, Feb. 24, 2012, the device supports faster download speeds than other phones, but today's wireless networks aren't equipped to supply those speeds. (AP Photo/Huawei)

This undated product image provided by Huawei, shows the Chinese company's new flagship model that it calls "the fastest smartphone in the world." The company said Sunday, Feb. 24, 2013, the device supports faster download speeds than other phones, but today's wireless networks aren't equipped to supply those speeds. The new phone, the Ascend P2, will have a 4.7 inch screen. (AP Photo/Huawei)

(AP) ? Huawei, a Chinese company that recently became the world's third-largest maker of smartphones, calls its new flagship product "the fastest smartphone in the world" and wants to use it to expand global awareness of its brand.

Parts of the presentation of the phone at a press conference Sunday in Barcelona, Spain, suggest that the company has some way to go in polishing its pitch for a global audience.

Richard Yu, head of Huawei's consumer business group said the new phone can be programmed to display more than 100 different "themes," or looks. This is important because "ladies like flowers, colorful things," Yu said.

Yu also said Huawei is learning from Apple how to make Google's Android software easier to use, a lawsuit-friendly utterance considering that Apple is on a global campaign to sue makers of Android phones for copying from the iPhone.

The new phone, the Ascend P2, will have a 4.7 inch screen. Yu said it will be available in the April to June time frame for about $525 without a contract. It's the "fastest" because it supports faster download speeds than other phones. However, today's wireless networks aren't equipped to supply those speeds.

Huawei Technologies Ltd. was the world's third largest seller of smartphones, after Samsung and Apple, in the fourth quarter of last year, according to research firm IDC. That's despite selling very few phones in the U.S., where the big phone companies mostly ignore it. It has a much better position in Europe, where cellphone companies have embraced its network equipment, and France's Orange is committed to selling the phone.

In the U.S., a congressional panel recommended in October that phone carriers avoid doing business with Huawei or its smaller Chinese rival, ZTE Corp., for fear that its network equipment could contain "back doors" that enable access to communications from outside. The Chinese government rejected the report as false and an effort to block Chinese companies from the U.S. market.

Meanwhile, a report by a private U.S. cybersecurity firm concluded recently that a special unit of China's military is responsible for sustained cyberespionage against U.S. companies and government agencies. China has denied involvement in the attacks in which massive amounts of data and corporate trade secrets, likely worth hundreds of millions of dollars, were stolen.

"It has not been an easy journey for us," Huawei's global brand director, Amy Lou, said Sunday of the company's quest to become globally recognized and trusted. She called the company "a great consumer brand in the making."

The world's largest cellphone trade show, Mobile World Congress, opens Monday in Barcelona.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-02-24-EU-TEC-Wireless-Show-Huawei/id-4aa513a984bd45b29a79dd7320911b02

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UCLA researchers further refine 'NanoVelcro' device to grab single cancer cells from blood: Improvement enables 'liquid biopsies' for metastatic melanoma

Home > Press > UCLA researchers further refine 'NanoVelcro' device to grab single cancer cells from blood: Improvement enables 'liquid biopsies' for metastatic melanoma

Abstract:
Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients' tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

Los Angeles, CA | Posted on February 23rd, 2013

Circulating tumor cells, or CTCs, play a crucial role in cancer metastasis, spreading from tumors to other parts of the body, where they form new tumors. When these cells are isolated from the blood early on, they can provide doctors with critical information about the type of cancer a patient has, the characteristics of the individual cancer and the potential progression of the disease. Doctors can also tell from these cells how to tailor a personalized treatment to a specific patient.

In recent years, a UCLA research team led by Hsian-Rong Tseng, an associate professor of molecular and medical pharmacology at the Crump Institute for Molecular Imaging and a member of both the California NanoSystems Institute at UCLA and UCLA's Jonsson Comprehensive Cancer Center, has developed a "NanoVelcro" chip. When blood is passed through the chip, extremely small "hairs" ? nanoscale wires or fibers coated with protein antibodies that match proteins on the surface of cancer cells ? act like Velcro, traping CTCs and isolating them for analysis.

CTCs trapped by the chip also act as a "liquid biopsy" of the tumor, providing convenient access to tumor cells and earlier information about potentially fatal metastases.

Histopathology ? the study of the microscopic structure of biopsy samples ? is currently considered the gold standard for determining tumor status, but in the early stages of metastasis, it is often difficult to identify a biopsy site. By being able to extract viable CTCs from the blood with the NanoVelcro chip, however, doctors can perform a detailed analysis of the cancer type and the various genetic characteristics of a patient's specific cancer.

Improving the NanoVelcro device

Tseng's team now reports that they have improved the NanoVelcro chip by replacing its original non-transparent silicon nanowire substrate inside with a new type of transparent polymer nanofiber-deposited substrate, allowing the device's nanowires to better "grab" cancer cells as blood passes by them.

Tseng and his colleagues were able to pick single CTCs immobilized on the new transparent substrate by using a miniaturized laser beam knife, a technique called laser micro-dissection, or LMD.

The researchers' paper on their improvement to the chip was published online Feb. 22 in the peer-reviewed journal Angewandte Chemie and is featured on the cover of the journal's March 2013 print issue.

"This paper summarizes a major milestone in the continuous development of NanoVelcro assays pioneered by our research group," Tseng said. "We now can not only capture cancer cells from blood with high efficiency but also hand-pick single CTCs for in-depth characterization to provide crucial information that helps doctors make better decisions."

Testing the improvements on melanoma

Using the new assay on patients' blood containing circulating melanoma cells (CMCs), Tseng's team was able to isolate and preserve single CMCs. Melanoma is a deadly type of skin cancer that is prone to spreading quickly throughout the body. The ability to capture and preserve single CMCs allows doctors to analyze melanoma cells' DNA structure, determine the genetic characteristics of the patient's cancer and confirm that the circulating cells remain genetically similar to the tumor they came from.

The preservation of single captured CMCs in this proof-of-concept study also allowed researchers to conduct an analysis ? called single-cell genotyping ? to find within the cell a specific target (BRAF V600E) for a drug called vemurafenib. BRAF V600E is a mutation in the BRAF protein that appears in approximately 60 percent of melanoma cases. Drugs that inhibit BRAF are able to slow and often reverse the growth of melanoma tumors.

"With this technology, we are getting closer to the goal of a widely clinically applicable liquid biopsy, where we can sample cancer cells by a simple blood draw and understand the genes that allow them to grow," said Dr. Antoni Ribas, a professor of medicine in the division of hematology-oncology, a Jonsson Cancer Center member and one of Tseng's key collaborators. "With the NanoVelcro chips, we will be able to better personalize treatments to patients by giving the right treatment to stop what makes that particular cancer grow."

Dr. Roger Lo, another key Tseng collaborator and an assistant professor in UCLA's department of medicine, division of dermatology, and department of molecular and medical pharmacology, was also optimistic about the new method.

"This scientific advancement ? being able to capture the melanoma cells in transit in the blood and then perform genetic analysis on them ? will in principle allow us to track the genomic evolution of melanoma under BRAF-inhibitor therapy and understand better the development of drug resistance," said Lo, who is also a member of the Jonsson Cancer Center.

####

About UCLA
UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson Center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2012, the Jonsson Cancer Center was once again named among the nation's top 10 cancer centers by U.S. News & World Report, a ranking it has held for 12 of the last 13 years.

For more news, visit the UCLA Newsroom and follow us on Twitter.

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Contacts:
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Samsung backs UPC-led project to develop graphene-based micro-antennas February 23rd, 2013

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Discoveries

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Announcements

Samsung backs UPC-led project to develop graphene-based micro-antennas February 23rd, 2013

Light from Silicon Nanocrystal LEDs February 23rd, 2013

Formation of nanoparticles can now be studied molecule-by-molecule February 23rd, 2013

UCLA researchers develop new method of powering tiny devices February 23rd, 2013

Source: http://www.nanotech-now.com/news.cgi?story_id=46986

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Friday, February 22, 2013

Apple iPhone 5 Outsold Samsung Galaxy S3 In Q4 Of 2012

Posted: February 21, 2013

The Apple iPhone 5 is the king of the hill when it comes to smartphone sales. The fourth quarter numbers from 2012 are in, and the iPhone 5 was the clear winner in sales, beating out the Samsung Galaxy S3.

Apple?s victory comes despite a new ad campaign by Samsung that directly pitted the S3 against the iPhone 5 at the end of last year. Dazeinfo reports that the news for Apple is actually better than simply a win for the iPhone 5.

A financial report by Strategy Analytics shows that the Samsung Galaxy S3 actually finished third in sales behind both the iPhone 5 and the iPhone 4s.

Valuewalk reported that the iPhone 5 sold 27.4 million handsets in the fourth quarter of 2012, while the iPhone 4S sold 17.4 million. The numbers also show that Apple?s unit sales are going up.

The iPhone 5 unit sales increased from 6 million in the third quarter of 2012 (the quarter it was introduced) to 27.4 million units in the fourth quarter.

The Apple iPhone 4S didn?t see growth quite like that, but unit sales went from 16.2 million in Q3 to 17.4 in Q4. Conversely, Samsung actually saw its unit sales slip from the third to the fourth quarter of 2012.

The Samsung Galaxy S3 slipped from 18 million units sold in the third quarter to 15.4 million units in the fourth quarter of 2012. These sales numbers drastically affected the marketshares for both Apple and Samsung.

At the end of the third quarter, Samsung held 10.4 percent of the market while the iPhone 4S had 9.4 percent and the iPhone 5 had a paltry 3.5 percent (for a combined 12.9 percent of the market for Apple).

At the end of the fourth quarter, Samsung?s marketshare had fallen to 7.1 percent. Both the iPhone 4s (8 percent) and the iPhone 5 (12.6 percent) beat that number individually and combined to give Apple more than 20 percent of the market.

Samsung does have a return volley in the works with the impending release of the Galaxy S4. Will the Apple iPhone 5 be able to stay on top once Samsung?s new phone is released?

Source: http://feedproxy.google.com/~r/TheInquisitrTechnology/~3/5YqA1VrwABE/

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Taiwan media kingpin pushes hard on China ties

In this Sept. 16, 2011 photo, media mogul Tsai Eng-meng smiles during a public event in Taipei, Taiwan. Appearing last year before Taiwanese regulators, billionaire media magnate Tsai appeared perplexed over a decision to fine his flagship newspaper for carrying camouflaged advertising on behalf of China's Communist government. Tsai, whose pro-China views have made him a lightning rod for criticism on this island of 23 million people, is on the verge of expanding his already substantial Taiwanese media empire through the acquisition of a 32 percent share in Next Media, currently owned by Jimmy Lai, an outspoken anti-communist reviled by Beijing. (AP Photo/Jameson Wu)

In this Sept. 16, 2011 photo, media mogul Tsai Eng-meng smiles during a public event in Taipei, Taiwan. Appearing last year before Taiwanese regulators, billionaire media magnate Tsai appeared perplexed over a decision to fine his flagship newspaper for carrying camouflaged advertising on behalf of China's Communist government. Tsai, whose pro-China views have made him a lightning rod for criticism on this island of 23 million people, is on the verge of expanding his already substantial Taiwanese media empire through the acquisition of a 32 percent share in Next Media, currently owned by Jimmy Lai, an outspoken anti-communist reviled by Beijing. (AP Photo/Jameson Wu)

(AP) ? Appearing last year before Taiwanese regulators, billionaire media magnate Tsai Eng-meng appeared perplexed over a decision to fine his flagship newspaper for carrying camouflaged advertising on behalf of China's Communist government.

"I really don't understand this," said Tsai, who became Taiwan's richest individual by selling treacly rice crackers on the Chinese mainland through his Want Want China Holdings company. "I think they should allow me to make this money."

It was a vintage statement from a man Forbes magazine says is worth $8 billion and whose pro-China views have made him a lightning rod for criticism among many on this democratic island of 23 million people. Since purchasing Taiwan's China Times Group in 2008, the rough-hewn Tsai has burst like a meteor onto Taiwan's political scene, leveraging his China-derived fortune to promote a political union across the 160-kilometer- (100-mile-) wide Taiwan Strait. Despised by Taiwan's Beijing-wary opposition, the crew-cut 55-year old seems to roll effortlessly over his detractors, proudly flaunting his limited formal education and soaring business success.

Now he seems ready to roll over them again. Next month Taiwanese officials will rule on his bid to take a 32 percent share ? through his son ? in the Next Media Group, owned by Hong Kong's Jimmy Lai, an outspoken anti-communist reviled in Beijing. Next properties include Apple Daily, which is Taiwan's biggest selling newspaper, and Next Magazine, its pre-eminent investigative journal.

If the deal goes through, Tsai would add substantially to his existing ownership of another major newspaper, an influential business daily, a top-rated cable TV news station, and a popular terrestrial TV channel. Critics, who believe Tsai uses his media empire's consistently laudatory coverage of China to advance his mainland business interests, say this new level of clout could stifle Taiwan's press competition and even undermine its young democracy.

The controversy over Tsai and his expansive Taiwanese media holdings goes right to the heart of the dominant issue in Taiwanese politics: Whether the island should attempt to maintain the separate political identity from the mainland it has maintained since splitting apart from it amid civil war in 1949, or whether it should bow to China's increasing political and economic might and accept its sovereign sway. Taiwanese media, particularly the island's four national newspapers and its seven major 24-hour cable news stations, play a crucial role in the debate, using their columns and broadcasts to promote the competing pro-China and independence agendas of the two main political parties.

The strength of Tsai's pro-China views were underlined in January 2012 when he told the Washington Post newspaper that he unreservedly backed Taiwan's unification with the mainland. "I really hope that I can see that," he said. In the same article he also attacked the widely held belief that Chinese security forces killed hundreds if not thousands of demonstrators during pro-democracy protests around Beijing's Tiananmen Square in June 1989, citing the refusal of a phalanx of Chinese tanks to run over a famously bold protester as evidence of the forces' restraint.

Want Want's own internal newsletter reported in its December 2008 edition that during a meeting in Beijing, Tsai told Wang Yi, head of the Chinese government's Taiwan Affairs Office, that Tsai had acquired the China Times Group "in order to use the power of the press to advance relations between China and Taiwan." The newsletter quoted Wang as saying that if Tsai's company had any future needs "the Taiwan Affairs Office will do its best to help it, including giving support to its food business."

After a lengthy exchange of emails with a Tsai legal representative, Tsai declined to be interviewed for this article. Contacted by The Associated Press, his public relations department also declined to answer questions on Tsai's China attitudes and his plans for Next Media. "We do not plan on repeating ourselves again," wrote his son, Cai Shao-zhong, explaining that Tsai had outlined his views in other forums in the past.

Interviews with media figures and former employees help fill in the blanks about Tsai. They paint a picture of a hard charging, detail-oriented businessman, loyal to his friends, but implacably hostile to anyone he feels is getting in his way. They also suggest he either lacks an understanding of the role of the media in Taiwan's democracy or does not consider it important.

"My understanding of Tsai is that's he's a businessman, all his thinking is about business, and how to make money," said Ho Jung-shin, who left his job as deputy editor of Tsai's flagship China Times newspaper last year over what he said was Tsai's use of his sprawling media holdings to conduct vendettas against perceived enemies.

Ho said he was particularly upset by repeated China Times Group claims, which the group later backed away from, that a researcher at Taiwan's prestigious Academia Sinica paid university students to mount demonstrations against Tsai's efforts to purchase a major Taiwanese cable TV distribution system. Regulators on Wednesday nixed that deal, at least in its present form.

"He took this public trust and turned it into a personal tool," Ho said. "He's sees the media only as a tool to advance his own campaigns."

Other former China Times employees also lambast him for turning both the China Times newspaper and the CTi cable news station into rubber stamp apologists for China's authoritarian government. They cite a long litany of examples, including the two outlets' harsh criticism of the Dalai Lama during a 2009 Taiwan visit ? Beijing reviles the Tibetan spiritual leader for allegedly promoting Tibetan independence ? and the short shrift the outlets gave imprisoned Chinese dissident Liu Xiaobo when he was awarded the Nobel Peace prize in 2010.

Taiwanese newspaper columnist Antonio Chiang, a longtime Tsai acquaintance, said a key to understanding Tsai's larger than life personality is the intense pride he feels at having taken over his father's small food business as a young man in the late 1970s and building it into what is now China's largest snack food company, despite having never finished high school.

"He's always talking about how little education he had and how it didn't hurt him in the least," said Chiang, who strongly opposes Tsai's views on China. "He loves the fact that he has all these PhDs working for him and that they have to listen to what he says."

"This is a man with extremely strong will," Chiang said. "He's not very sophisticated but he's very self-controlled. And he's completely honest. What you see from him is exactly what you get."

The lack of pretense Chiang describes is reflected in Tsai's unpolished persona, which includes a shoot from the hip social style and a preference for his native Taiwanese dialect over the clipped, Mandarin Chinese employed by the better educated doyens of the Taiwanese business elite.

A 2012 Chinese language biography portrayed him as a simple man of the people, most comfortable chewing betel nut and conversing informally with food processing workers amid a hands-on management style that includes familiarity with every aspect of his business, from buying raw materials to managing production lines and kibitzing with customers.

But Chiang said that beneath Tsai's everyman personality is a single-minded approach that threatens Taiwan's free press, including the Apple Daily newspaper, Chiang's current employer, and Next Magazine, the investigative journal.

Apple, while better known for its racy diet of sex, scandal and celebrity gossip, has also been praised for its editorial independence that sets it apart from most other Taiwanese media outlets, which seem most comfortable parroting the views of one or the other of Taiwan's two main political parties.

"He ruined the China Times," Chiang said. "He can ruin Apple as well."

Tsai has also stirred controversy by taking initiatives that appear aimed at bringing Taiwan and China closer together on important foreign policy questions.

Last September, Tsai contributed five million New Taiwan dollars ($166,000) to underwrite the voyage of some 60 Taiwanese fishing vessels to an island group in the East China Sea hotly contested by China and Japan. The voyage ended in a confrontation between Japanese and Taiwanese coast guard cutters, significantly raising tensions in the area, despite the declared intention of Taiwanese President Ma Ying-jeou to avoid taking provocative actions on the sensitive island issue.

Fishermen involved in the demonstration said they were only interested in asserting their fishing rights around the Diaoyu, or Senkaku islands, and had no interest in politics, or making common cause with China. But 11 days after they returned to Taiwan, the China Times ran a hard-hitting editorial, calling on the Taiwanese government to join Beijing in pushing for Chinese sovereignty there.

Initiatives like this are feeding the belief among Tsai critics that he and other deep-pocketed Taiwanese business people are attempting to subvert the Ma government's relatively cautious China policy, which while consciously moving the island ever closer to Beijing economically, still opposes an early political union.

"These business people are definitely pushing the two sides closer together," said Ketty Chen, a Taiwanese-American academic at Taipei's National Taiwan University. "They're very influential."

Arrayed against the influence of Tsai and his pro-China allies is Taiwan's boisterous democracy and the blossoming among many Taiwanese of a political and cultural identity distinct from the mainland.

"I wouldn't sell Taiwan short," said Taiwan expert Mark Harrison of the University of Tasmania in Australia. . "It won't surrender without a fight. This battle isn't over."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-22-Taiwan-Mogul%20On%20The%20March/id-f9e97212ef1d4b7b880f6396262fbdf7

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